diff --git a/sycl/source/detail/kernel_impl.cpp b/sycl/source/detail/kernel_impl.cpp
index 1a4bd03d33b7f..052d9bdcfdc77 100644
--- a/sycl/source/detail/kernel_impl.cpp
+++ b/sycl/source/detail/kernel_impl.cpp
@@ -27,6 +27,11 @@ kernel_impl::kernel_impl(RT::PiKernel Kernel, ContextImplPtr Context)
   // Let the runtime caller handle native kernel retaining in other cases if
   // it's needed.
   getPlugin().call<PiApiKind::piKernelRetain>(MKernel);
+  // Enable USM indirect access for interoperability kernels.
+  // Some PI Plugins (like OpenCL) require this call to enable USM
+  // For others, PI will turn this into a NOP.
+  getPlugin().call<PiApiKind::piKernelSetExecInfo>(
+      MKernel, PI_USM_INDIRECT_ACCESS, sizeof(pi_bool), &PI_TRUE);
 }
 
 kernel_impl::kernel_impl(RT::PiKernel Kernel, ContextImplPtr ContextImpl,
diff --git a/sycl/test/usm/source_kernel_indirect_access.cpp b/sycl/test/usm/source_kernel_indirect_access.cpp
new file mode 100644
index 0000000000000..1ce8814ac63ba
--- /dev/null
+++ b/sycl/test/usm/source_kernel_indirect_access.cpp
@@ -0,0 +1,56 @@
+// RUN: %clangxx -fsycl -fsycl-targets=%sycl_triple -lOpenCL %s -o %t1.out
+// RUN: %CPU_RUN_PLACEHOLDER %t1.out
+// RUN: %GPU_RUN_PLACEHOLDER %t1.out
+// REQUIRES: opencl
+
+#include <CL/cl.h>
+#include <CL/sycl.hpp>
+
+using namespace sycl;
+
+static const char *Src = R"(
+kernel void test(global ulong *PSrc, global ulong *PDst) {
+    global int *Src = (global int *) *PSrc;
+    global int *Dst = (global int *) *PDst;
+    int Old = *Src, New = Old + 1;
+    printf("Read %d from %p; write %d to %p\n", Old, Src, New, Dst);
+    *Dst = New;
+}
+)";
+
+int main() {
+  queue Q{};
+
+  cl_context Ctx = Q.get_context().get();
+  cl_program Prog = clCreateProgramWithSource(Ctx, 1, &Src, NULL, NULL);
+  clBuildProgram(Prog, 0, NULL, NULL, NULL, NULL);
+
+  cl_kernel OclKernel = clCreateKernel(Prog, "test", NULL);
+
+  cl::sycl::kernel SyclKernel(OclKernel, Q.get_context());
+
+  auto POuter = malloc_shared<int *>(1, Q);
+  auto PInner = malloc_shared<int>(1, Q);
+  auto QOuter = malloc_shared<int *>(1, Q);
+  auto QInner = malloc_shared<int>(1, Q);
+
+  *PInner = 4;
+  *POuter = PInner;
+  *QInner = 0;
+  *QOuter = QInner;
+
+  Q.submit([&](handler &CGH) {
+     CGH.set_arg(0, POuter);
+     CGH.set_arg(1, QOuter);
+     CGH.parallel_for(cl::sycl::range<1>(1), SyclKernel);
+   }).wait();
+
+  assert(*PInner == 4 && "Read value is corrupted");
+  assert(*QInner == 5 && "Value value is incorrect");
+
+  std::cout << "Increment: " << *PInner << " -> " << *QInner << std::endl;
+
+  clReleaseKernel(OclKernel);
+  clReleaseProgram(Prog);
+  clReleaseContext(Ctx);
+}