diff --git a/llvm/lib/Target/NVPTX/NVPTXISelLowering.cpp b/llvm/lib/Target/NVPTX/NVPTXISelLowering.cpp
index bb76ffdfd99d7..5c5766a8b2345 100644
--- a/llvm/lib/Target/NVPTX/NVPTXISelLowering.cpp
+++ b/llvm/lib/Target/NVPTX/NVPTXISelLowering.cpp
@@ -6038,7 +6038,11 @@ static SDValue PerformLOADCombine(SDNode *N,
   // elements can be optimised away instead of being needlessly split during
   // legalization, which involves storing to the stack and loading it back.
   EVT VT = N->getValueType(0);
-  if (VT != MVT::v16i8)
+  bool CorrectlyAligned =
+      DCI.DAG.getTargetLoweringInfo().allowsMemoryAccessForAlignment(
+          *DAG.getContext(), DAG.getDataLayout(), LD->getMemoryVT(),
+          *LD->getMemOperand());
+  if (!(VT == MVT::v16i8 && CorrectlyAligned))
     return SDValue();
 
   SDLoc DL(N);
diff --git a/llvm/test/CodeGen/NVPTX/LoadStoreVectorizer.ll b/llvm/test/CodeGen/NVPTX/LoadStoreVectorizer.ll
index 868a06e2a850c..bc58a700cb982 100644
--- a/llvm/test/CodeGen/NVPTX/LoadStoreVectorizer.ll
+++ b/llvm/test/CodeGen/NVPTX/LoadStoreVectorizer.ll
@@ -1,3 +1,4 @@
+; NOTE: Assertions have been autogenerated by utils/update_llc_test_checks.py UTC_ARGS: --version 5
 ; RUN: llc < %s | FileCheck -check-prefix=ENABLED %s
 ; RUN: llc -disable-nvptx-load-store-vectorizer < %s | FileCheck -check-prefix=DISABLED %s
 ; RUN: %if ptxas %{ llc < %s | %ptxas-verify %}
@@ -8,10 +9,31 @@ target triple = "nvptx64-nvidia-cuda"
 ; Check that the load-store vectorizer is enabled by default for nvptx, and
 ; that it's disabled by the appropriate flag.
 
-; ENABLED: ld.v2.{{.}}32
-; DISABLED: ld.{{.}}32
-; DISABLED: ld.{{.}}32
 define i32 @f(ptr %p) {
+; ENABLED-LABEL: f(
+; ENABLED:       {
+; ENABLED-NEXT:    .reg .b32 %r<4>;
+; ENABLED-NEXT:    .reg .b64 %rd<2>;
+; ENABLED-EMPTY:
+; ENABLED-NEXT:  // %bb.0:
+; ENABLED-NEXT:    ld.param.u64 %rd1, [f_param_0];
+; ENABLED-NEXT:    ld.v2.u32 {%r1, %r2}, [%rd1];
+; ENABLED-NEXT:    add.s32 %r3, %r1, %r2;
+; ENABLED-NEXT:    st.param.b32 [func_retval0+0], %r3;
+; ENABLED-NEXT:    ret;
+;
+; DISABLED-LABEL: f(
+; DISABLED:       {
+; DISABLED-NEXT:    .reg .b32 %r<4>;
+; DISABLED-NEXT:    .reg .b64 %rd<2>;
+; DISABLED-EMPTY:
+; DISABLED-NEXT:  // %bb.0:
+; DISABLED-NEXT:    ld.param.u64 %rd1, [f_param_0];
+; DISABLED-NEXT:    ld.u32 %r1, [%rd1];
+; DISABLED-NEXT:    ld.u32 %r2, [%rd1+4];
+; DISABLED-NEXT:    add.s32 %r3, %r1, %r2;
+; DISABLED-NEXT:    st.param.b32 [func_retval0+0], %r3;
+; DISABLED-NEXT:    ret;
   %p.1 = getelementptr i32, ptr %p, i32 1
   %v0 = load i32, ptr %p, align 8
   %v1 = load i32, ptr %p.1, align 4
@@ -20,6 +42,66 @@ define i32 @f(ptr %p) {
 }
 
 define half @fh(ptr %p) {
+; ENABLED-LABEL: fh(
+; ENABLED:       {
+; ENABLED-NEXT:    .reg .b16 %rs<10>;
+; ENABLED-NEXT:    .reg .f32 %f<13>;
+; ENABLED-NEXT:    .reg .b64 %rd<2>;
+; ENABLED-EMPTY:
+; ENABLED-NEXT:  // %bb.0:
+; ENABLED-NEXT:    ld.param.u64 %rd1, [fh_param_0];
+; ENABLED-NEXT:    ld.v4.b16 {%rs1, %rs2, %rs3, %rs4}, [%rd1];
+; ENABLED-NEXT:    ld.b16 %rs5, [%rd1+8];
+; ENABLED-NEXT:    cvt.f32.f16 %f1, %rs2;
+; ENABLED-NEXT:    cvt.f32.f16 %f2, %rs1;
+; ENABLED-NEXT:    add.rn.f32 %f3, %f2, %f1;
+; ENABLED-NEXT:    cvt.rn.f16.f32 %rs6, %f3;
+; ENABLED-NEXT:    cvt.f32.f16 %f4, %rs4;
+; ENABLED-NEXT:    cvt.f32.f16 %f5, %rs3;
+; ENABLED-NEXT:    add.rn.f32 %f6, %f5, %f4;
+; ENABLED-NEXT:    cvt.rn.f16.f32 %rs7, %f6;
+; ENABLED-NEXT:    cvt.f32.f16 %f7, %rs7;
+; ENABLED-NEXT:    cvt.f32.f16 %f8, %rs6;
+; ENABLED-NEXT:    add.rn.f32 %f9, %f8, %f7;
+; ENABLED-NEXT:    cvt.rn.f16.f32 %rs8, %f9;
+; ENABLED-NEXT:    cvt.f32.f16 %f10, %rs8;
+; ENABLED-NEXT:    cvt.f32.f16 %f11, %rs5;
+; ENABLED-NEXT:    add.rn.f32 %f12, %f10, %f11;
+; ENABLED-NEXT:    cvt.rn.f16.f32 %rs9, %f12;
+; ENABLED-NEXT:    st.param.b16 [func_retval0+0], %rs9;
+; ENABLED-NEXT:    ret;
+;
+; DISABLED-LABEL: fh(
+; DISABLED:       {
+; DISABLED-NEXT:    .reg .b16 %rs<10>;
+; DISABLED-NEXT:    .reg .f32 %f<13>;
+; DISABLED-NEXT:    .reg .b64 %rd<2>;
+; DISABLED-EMPTY:
+; DISABLED-NEXT:  // %bb.0:
+; DISABLED-NEXT:    ld.param.u64 %rd1, [fh_param_0];
+; DISABLED-NEXT:    ld.b16 %rs1, [%rd1];
+; DISABLED-NEXT:    ld.b16 %rs2, [%rd1+2];
+; DISABLED-NEXT:    ld.b16 %rs3, [%rd1+4];
+; DISABLED-NEXT:    ld.b16 %rs4, [%rd1+6];
+; DISABLED-NEXT:    ld.b16 %rs5, [%rd1+8];
+; DISABLED-NEXT:    cvt.f32.f16 %f1, %rs2;
+; DISABLED-NEXT:    cvt.f32.f16 %f2, %rs1;
+; DISABLED-NEXT:    add.rn.f32 %f3, %f2, %f1;
+; DISABLED-NEXT:    cvt.rn.f16.f32 %rs6, %f3;
+; DISABLED-NEXT:    cvt.f32.f16 %f4, %rs4;
+; DISABLED-NEXT:    cvt.f32.f16 %f5, %rs3;
+; DISABLED-NEXT:    add.rn.f32 %f6, %f5, %f4;
+; DISABLED-NEXT:    cvt.rn.f16.f32 %rs7, %f6;
+; DISABLED-NEXT:    cvt.f32.f16 %f7, %rs7;
+; DISABLED-NEXT:    cvt.f32.f16 %f8, %rs6;
+; DISABLED-NEXT:    add.rn.f32 %f9, %f8, %f7;
+; DISABLED-NEXT:    cvt.rn.f16.f32 %rs8, %f9;
+; DISABLED-NEXT:    cvt.f32.f16 %f10, %rs8;
+; DISABLED-NEXT:    cvt.f32.f16 %f11, %rs5;
+; DISABLED-NEXT:    add.rn.f32 %f12, %f10, %f11;
+; DISABLED-NEXT:    cvt.rn.f16.f32 %rs9, %f12;
+; DISABLED-NEXT:    st.param.b16 [func_retval0+0], %rs9;
+; DISABLED-NEXT:    ret;
   %p.1 = getelementptr half, ptr %p, i32 1
   %p.2 = getelementptr half, ptr %p, i32 2
   %p.3 = getelementptr half, ptr %p, i32 3
@@ -37,6 +119,40 @@ define half @fh(ptr %p) {
 }
 
 define float @ff(ptr %p) {
+; ENABLED-LABEL: ff(
+; ENABLED:       {
+; ENABLED-NEXT:    .reg .f32 %f<10>;
+; ENABLED-NEXT:    .reg .b64 %rd<2>;
+; ENABLED-EMPTY:
+; ENABLED-NEXT:  // %bb.0:
+; ENABLED-NEXT:    ld.param.u64 %rd1, [ff_param_0];
+; ENABLED-NEXT:    ld.v4.f32 {%f1, %f2, %f3, %f4}, [%rd1];
+; ENABLED-NEXT:    ld.f32 %f5, [%rd1+16];
+; ENABLED-NEXT:    add.rn.f32 %f6, %f1, %f2;
+; ENABLED-NEXT:    add.rn.f32 %f7, %f3, %f4;
+; ENABLED-NEXT:    add.rn.f32 %f8, %f6, %f7;
+; ENABLED-NEXT:    add.rn.f32 %f9, %f8, %f5;
+; ENABLED-NEXT:    st.param.f32 [func_retval0+0], %f9;
+; ENABLED-NEXT:    ret;
+;
+; DISABLED-LABEL: ff(
+; DISABLED:       {
+; DISABLED-NEXT:    .reg .f32 %f<10>;
+; DISABLED-NEXT:    .reg .b64 %rd<2>;
+; DISABLED-EMPTY:
+; DISABLED-NEXT:  // %bb.0:
+; DISABLED-NEXT:    ld.param.u64 %rd1, [ff_param_0];
+; DISABLED-NEXT:    ld.f32 %f1, [%rd1];
+; DISABLED-NEXT:    ld.f32 %f2, [%rd1+4];
+; DISABLED-NEXT:    ld.f32 %f3, [%rd1+8];
+; DISABLED-NEXT:    ld.f32 %f4, [%rd1+12];
+; DISABLED-NEXT:    ld.f32 %f5, [%rd1+16];
+; DISABLED-NEXT:    add.rn.f32 %f6, %f1, %f2;
+; DISABLED-NEXT:    add.rn.f32 %f7, %f3, %f4;
+; DISABLED-NEXT:    add.rn.f32 %f8, %f6, %f7;
+; DISABLED-NEXT:    add.rn.f32 %f9, %f8, %f5;
+; DISABLED-NEXT:    st.param.f32 [func_retval0+0], %f9;
+; DISABLED-NEXT:    ret;
   %p.1 = getelementptr float, ptr %p, i32 1
   %p.2 = getelementptr float, ptr %p, i32 2
   %p.3 = getelementptr float, ptr %p, i32 3
@@ -54,8 +170,90 @@ define float @ff(ptr %p) {
 }
 
 define void @combine_v16i8(ptr noundef align 16 %ptr1, ptr noundef align 16 %ptr2) {
-  ; ENABLED-LABEL: combine_v16i8
-  ; ENABLED: ld.v4.u32
+; ENABLED-LABEL: combine_v16i8(
+; ENABLED:       {
+; ENABLED-NEXT:    .reg .b32 %r<40>;
+; ENABLED-NEXT:    .reg .b64 %rd<3>;
+; ENABLED-EMPTY:
+; ENABLED-NEXT:  // %bb.0:
+; ENABLED-NEXT:    ld.param.u64 %rd1, [combine_v16i8_param_0];
+; ENABLED-NEXT:    ld.v4.u32 {%r1, %r2, %r3, %r4}, [%rd1];
+; ENABLED-NEXT:    ld.param.u64 %rd2, [combine_v16i8_param_1];
+; ENABLED-NEXT:    bfe.u32 %r9, %r1, 0, 8;
+; ENABLED-NEXT:    bfe.u32 %r10, %r1, 8, 8;
+; ENABLED-NEXT:    bfe.u32 %r11, %r1, 16, 8;
+; ENABLED-NEXT:    bfe.u32 %r12, %r1, 24, 8;
+; ENABLED-NEXT:    bfe.u32 %r13, %r2, 0, 8;
+; ENABLED-NEXT:    bfe.u32 %r14, %r2, 8, 8;
+; ENABLED-NEXT:    bfe.u32 %r15, %r2, 16, 8;
+; ENABLED-NEXT:    bfe.u32 %r16, %r2, 24, 8;
+; ENABLED-NEXT:    bfe.u32 %r17, %r3, 0, 8;
+; ENABLED-NEXT:    bfe.u32 %r18, %r3, 8, 8;
+; ENABLED-NEXT:    bfe.u32 %r19, %r3, 16, 8;
+; ENABLED-NEXT:    bfe.u32 %r20, %r3, 24, 8;
+; ENABLED-NEXT:    bfe.u32 %r21, %r4, 0, 8;
+; ENABLED-NEXT:    bfe.u32 %r22, %r4, 8, 8;
+; ENABLED-NEXT:    bfe.u32 %r23, %r4, 16, 8;
+; ENABLED-NEXT:    bfe.u32 %r24, %r4, 24, 8;
+; ENABLED-NEXT:    add.s32 %r25, %r9, %r10;
+; ENABLED-NEXT:    add.s32 %r26, %r25, %r11;
+; ENABLED-NEXT:    add.s32 %r27, %r26, %r12;
+; ENABLED-NEXT:    add.s32 %r28, %r27, %r13;
+; ENABLED-NEXT:    add.s32 %r29, %r28, %r14;
+; ENABLED-NEXT:    add.s32 %r30, %r29, %r15;
+; ENABLED-NEXT:    add.s32 %r31, %r30, %r16;
+; ENABLED-NEXT:    add.s32 %r32, %r31, %r17;
+; ENABLED-NEXT:    add.s32 %r33, %r32, %r18;
+; ENABLED-NEXT:    add.s32 %r34, %r33, %r19;
+; ENABLED-NEXT:    add.s32 %r35, %r34, %r20;
+; ENABLED-NEXT:    add.s32 %r36, %r35, %r21;
+; ENABLED-NEXT:    add.s32 %r37, %r36, %r22;
+; ENABLED-NEXT:    add.s32 %r38, %r37, %r23;
+; ENABLED-NEXT:    add.s32 %r39, %r38, %r24;
+; ENABLED-NEXT:    st.u32 [%rd2], %r39;
+; ENABLED-NEXT:    ret;
+;
+; DISABLED-LABEL: combine_v16i8(
+; DISABLED:       {
+; DISABLED-NEXT:    .reg .b32 %r<32>;
+; DISABLED-NEXT:    .reg .b64 %rd<3>;
+; DISABLED-EMPTY:
+; DISABLED-NEXT:  // %bb.0:
+; DISABLED-NEXT:    ld.param.u64 %rd1, [combine_v16i8_param_0];
+; DISABLED-NEXT:    ld.u8 %r1, [%rd1];
+; DISABLED-NEXT:    ld.param.u64 %rd2, [combine_v16i8_param_1];
+; DISABLED-NEXT:    ld.u8 %r2, [%rd1+1];
+; DISABLED-NEXT:    ld.u8 %r3, [%rd1+2];
+; DISABLED-NEXT:    ld.u8 %r4, [%rd1+3];
+; DISABLED-NEXT:    ld.u8 %r5, [%rd1+4];
+; DISABLED-NEXT:    ld.u8 %r6, [%rd1+5];
+; DISABLED-NEXT:    ld.u8 %r7, [%rd1+6];
+; DISABLED-NEXT:    ld.u8 %r8, [%rd1+7];
+; DISABLED-NEXT:    ld.u8 %r9, [%rd1+8];
+; DISABLED-NEXT:    ld.u8 %r10, [%rd1+9];
+; DISABLED-NEXT:    ld.u8 %r11, [%rd1+10];
+; DISABLED-NEXT:    ld.u8 %r12, [%rd1+11];
+; DISABLED-NEXT:    ld.u8 %r13, [%rd1+12];
+; DISABLED-NEXT:    ld.u8 %r14, [%rd1+13];
+; DISABLED-NEXT:    ld.u8 %r15, [%rd1+14];
+; DISABLED-NEXT:    ld.u8 %r16, [%rd1+15];
+; DISABLED-NEXT:    add.s32 %r17, %r1, %r2;
+; DISABLED-NEXT:    add.s32 %r18, %r17, %r3;
+; DISABLED-NEXT:    add.s32 %r19, %r18, %r4;
+; DISABLED-NEXT:    add.s32 %r20, %r19, %r5;
+; DISABLED-NEXT:    add.s32 %r21, %r20, %r6;
+; DISABLED-NEXT:    add.s32 %r22, %r21, %r7;
+; DISABLED-NEXT:    add.s32 %r23, %r22, %r8;
+; DISABLED-NEXT:    add.s32 %r24, %r23, %r9;
+; DISABLED-NEXT:    add.s32 %r25, %r24, %r10;
+; DISABLED-NEXT:    add.s32 %r26, %r25, %r11;
+; DISABLED-NEXT:    add.s32 %r27, %r26, %r12;
+; DISABLED-NEXT:    add.s32 %r28, %r27, %r13;
+; DISABLED-NEXT:    add.s32 %r29, %r28, %r14;
+; DISABLED-NEXT:    add.s32 %r30, %r29, %r15;
+; DISABLED-NEXT:    add.s32 %r31, %r30, %r16;
+; DISABLED-NEXT:    st.u32 [%rd2], %r31;
+; DISABLED-NEXT:    ret;
   %val0 = load i8, ptr %ptr1, align 16
   %ptr1.1 = getelementptr inbounds i8, ptr %ptr1, i64 1
   %val1 = load i8, ptr %ptr1.1, align 1
@@ -122,9 +320,219 @@ define void @combine_v16i8(ptr noundef align 16 %ptr1, ptr noundef align 16 %ptr
   ret void
 }
 
+define void @combine_v16i8_unaligned(ptr noundef align 8 %ptr1, ptr noundef align 16 %ptr2) {
+; ENABLED-LABEL: combine_v16i8_unaligned(
+; ENABLED:       {
+; ENABLED-NEXT:    .reg .b32 %r<36>;
+; ENABLED-NEXT:    .reg .b64 %rd<3>;
+; ENABLED-EMPTY:
+; ENABLED-NEXT:  // %bb.0:
+; ENABLED-NEXT:    ld.param.u64 %rd1, [combine_v16i8_unaligned_param_0];
+; ENABLED-NEXT:    ld.u32 %r1, [%rd1+4];
+; ENABLED-NEXT:    ld.u32 %r2, [%rd1];
+; ENABLED-NEXT:    ld.param.u64 %rd2, [combine_v16i8_unaligned_param_1];
+; ENABLED-NEXT:    ld.u32 %r3, [%rd1+12];
+; ENABLED-NEXT:    ld.u32 %r4, [%rd1+8];
+; ENABLED-NEXT:    bfe.u32 %r5, %r2, 0, 8;
+; ENABLED-NEXT:    bfe.u32 %r6, %r2, 8, 8;
+; ENABLED-NEXT:    bfe.u32 %r7, %r2, 16, 8;
+; ENABLED-NEXT:    bfe.u32 %r8, %r2, 24, 8;
+; ENABLED-NEXT:    bfe.u32 %r9, %r1, 0, 8;
+; ENABLED-NEXT:    bfe.u32 %r10, %r1, 8, 8;
+; ENABLED-NEXT:    bfe.u32 %r11, %r1, 16, 8;
+; ENABLED-NEXT:    bfe.u32 %r12, %r1, 24, 8;
+; ENABLED-NEXT:    bfe.u32 %r13, %r4, 0, 8;
+; ENABLED-NEXT:    bfe.u32 %r14, %r4, 8, 8;
+; ENABLED-NEXT:    bfe.u32 %r15, %r4, 16, 8;
+; ENABLED-NEXT:    bfe.u32 %r16, %r4, 24, 8;
+; ENABLED-NEXT:    bfe.u32 %r17, %r3, 0, 8;
+; ENABLED-NEXT:    bfe.u32 %r18, %r3, 8, 8;
+; ENABLED-NEXT:    bfe.u32 %r19, %r3, 16, 8;
+; ENABLED-NEXT:    bfe.u32 %r20, %r3, 24, 8;
+; ENABLED-NEXT:    add.s32 %r21, %r5, %r6;
+; ENABLED-NEXT:    add.s32 %r22, %r21, %r7;
+; ENABLED-NEXT:    add.s32 %r23, %r22, %r8;
+; ENABLED-NEXT:    add.s32 %r24, %r23, %r9;
+; ENABLED-NEXT:    add.s32 %r25, %r24, %r10;
+; ENABLED-NEXT:    add.s32 %r26, %r25, %r11;
+; ENABLED-NEXT:    add.s32 %r27, %r26, %r12;
+; ENABLED-NEXT:    add.s32 %r28, %r27, %r13;
+; ENABLED-NEXT:    add.s32 %r29, %r28, %r14;
+; ENABLED-NEXT:    add.s32 %r30, %r29, %r15;
+; ENABLED-NEXT:    add.s32 %r31, %r30, %r16;
+; ENABLED-NEXT:    add.s32 %r32, %r31, %r17;
+; ENABLED-NEXT:    add.s32 %r33, %r32, %r18;
+; ENABLED-NEXT:    add.s32 %r34, %r33, %r19;
+; ENABLED-NEXT:    add.s32 %r35, %r34, %r20;
+; ENABLED-NEXT:    st.u32 [%rd2], %r35;
+; ENABLED-NEXT:    ret;
+;
+; DISABLED-LABEL: combine_v16i8_unaligned(
+; DISABLED:       {
+; DISABLED-NEXT:    .reg .b32 %r<32>;
+; DISABLED-NEXT:    .reg .b64 %rd<3>;
+; DISABLED-EMPTY:
+; DISABLED-NEXT:  // %bb.0:
+; DISABLED-NEXT:    ld.param.u64 %rd1, [combine_v16i8_unaligned_param_0];
+; DISABLED-NEXT:    ld.u8 %r1, [%rd1];
+; DISABLED-NEXT:    ld.param.u64 %rd2, [combine_v16i8_unaligned_param_1];
+; DISABLED-NEXT:    ld.u8 %r2, [%rd1+1];
+; DISABLED-NEXT:    ld.u8 %r3, [%rd1+2];
+; DISABLED-NEXT:    ld.u8 %r4, [%rd1+3];
+; DISABLED-NEXT:    ld.u8 %r5, [%rd1+4];
+; DISABLED-NEXT:    ld.u8 %r6, [%rd1+5];
+; DISABLED-NEXT:    ld.u8 %r7, [%rd1+6];
+; DISABLED-NEXT:    ld.u8 %r8, [%rd1+7];
+; DISABLED-NEXT:    ld.u8 %r9, [%rd1+8];
+; DISABLED-NEXT:    ld.u8 %r10, [%rd1+9];
+; DISABLED-NEXT:    ld.u8 %r11, [%rd1+10];
+; DISABLED-NEXT:    ld.u8 %r12, [%rd1+11];
+; DISABLED-NEXT:    ld.u8 %r13, [%rd1+12];
+; DISABLED-NEXT:    ld.u8 %r14, [%rd1+13];
+; DISABLED-NEXT:    ld.u8 %r15, [%rd1+14];
+; DISABLED-NEXT:    ld.u8 %r16, [%rd1+15];
+; DISABLED-NEXT:    add.s32 %r17, %r1, %r2;
+; DISABLED-NEXT:    add.s32 %r18, %r17, %r3;
+; DISABLED-NEXT:    add.s32 %r19, %r18, %r4;
+; DISABLED-NEXT:    add.s32 %r20, %r19, %r5;
+; DISABLED-NEXT:    add.s32 %r21, %r20, %r6;
+; DISABLED-NEXT:    add.s32 %r22, %r21, %r7;
+; DISABLED-NEXT:    add.s32 %r23, %r22, %r8;
+; DISABLED-NEXT:    add.s32 %r24, %r23, %r9;
+; DISABLED-NEXT:    add.s32 %r25, %r24, %r10;
+; DISABLED-NEXT:    add.s32 %r26, %r25, %r11;
+; DISABLED-NEXT:    add.s32 %r27, %r26, %r12;
+; DISABLED-NEXT:    add.s32 %r28, %r27, %r13;
+; DISABLED-NEXT:    add.s32 %r29, %r28, %r14;
+; DISABLED-NEXT:    add.s32 %r30, %r29, %r15;
+; DISABLED-NEXT:    add.s32 %r31, %r30, %r16;
+; DISABLED-NEXT:    st.u32 [%rd2], %r31;
+; DISABLED-NEXT:    ret;
+  %val0 = load i8, ptr %ptr1, align 8
+  %ptr1.1 = getelementptr inbounds i8, ptr %ptr1, i64 1
+  %val1 = load i8, ptr %ptr1.1, align 1
+  %ptr1.2 = getelementptr inbounds i8, ptr %ptr1, i64 2
+  %val2 = load i8, ptr %ptr1.2, align 2
+  %ptr1.3 = getelementptr inbounds i8, ptr %ptr1, i64 3
+  %val3 = load i8, ptr %ptr1.3, align 1
+  %ptr1.4 = getelementptr inbounds i8, ptr %ptr1, i64 4
+  %val4 = load i8, ptr %ptr1.4, align 4
+  %ptr1.5 = getelementptr inbounds i8, ptr %ptr1, i64 5
+  %val5 = load i8, ptr %ptr1.5, align 1
+  %ptr1.6 = getelementptr inbounds i8, ptr %ptr1, i64 6
+  %val6 = load i8, ptr %ptr1.6, align 2
+  %ptr1.7 = getelementptr inbounds i8, ptr %ptr1, i64 7
+  %val7 = load i8, ptr %ptr1.7, align 1
+  %ptr1.8 = getelementptr inbounds i8, ptr %ptr1, i64 8
+  %val8 = load i8, ptr %ptr1.8, align 8
+  %ptr1.9 = getelementptr inbounds i8, ptr %ptr1, i64 9
+  %val9 = load i8, ptr %ptr1.9, align 1
+  %ptr1.10 = getelementptr inbounds i8, ptr %ptr1, i64 10
+  %val10 = load i8, ptr %ptr1.10, align 2
+  %ptr1.11 = getelementptr inbounds i8, ptr %ptr1, i64 11
+  %val11 = load i8, ptr %ptr1.11, align 1
+  %ptr1.12 = getelementptr inbounds i8, ptr %ptr1, i64 12
+  %val12 = load i8, ptr %ptr1.12, align 4
+  %ptr1.13 = getelementptr inbounds i8, ptr %ptr1, i64 13
+  %val13 = load i8, ptr %ptr1.13, align 1
+  %ptr1.14 = getelementptr inbounds i8, ptr %ptr1, i64 14
+  %val14 = load i8, ptr %ptr1.14, align 2
+  %ptr1.15 = getelementptr inbounds i8, ptr %ptr1, i64 15
+  %val15 = load i8, ptr %ptr1.15, align 1
+  %lane0 = zext i8 %val0 to i32
+  %lane1 = zext i8 %val1 to i32
+  %lane2 = zext i8 %val2 to i32
+  %lane3 = zext i8 %val3 to i32
+  %lane4 = zext i8 %val4 to i32
+  %lane5 = zext i8 %val5 to i32
+  %lane6 = zext i8 %val6 to i32
+  %lane7 = zext i8 %val7 to i32
+  %lane8 = zext i8 %val8 to i32
+  %lane9 = zext i8 %val9 to i32
+  %lane10 = zext i8 %val10 to i32
+  %lane11 = zext i8 %val11 to i32
+  %lane12 = zext i8 %val12 to i32
+  %lane13 = zext i8 %val13 to i32
+  %lane14 = zext i8 %val14 to i32
+  %lane15 = zext i8 %val15 to i32
+  %red.1 = add i32 %lane0, %lane1
+  %red.2 = add i32 %red.1, %lane2
+  %red.3 = add i32 %red.2, %lane3
+  %red.4 = add i32 %red.3, %lane4
+  %red.5 = add i32 %red.4, %lane5
+  %red.6 = add i32 %red.5, %lane6
+  %red.7 = add i32 %red.6, %lane7
+  %red.8 = add i32 %red.7, %lane8
+  %red.9 = add i32 %red.8, %lane9
+  %red.10 = add i32 %red.9, %lane10
+  %red.11 = add i32 %red.10, %lane11
+  %red.12 = add i32 %red.11, %lane12
+  %red.13 = add i32 %red.12, %lane13
+  %red.14 = add i32 %red.13, %lane14
+  %red = add i32 %red.14, %lane15
+  store i32 %red, ptr %ptr2, align 4
+  ret void
+}
+
+
 define void @combine_v8i16(ptr noundef align 16 %ptr1, ptr noundef align 16 %ptr2) {
-  ; ENABLED-LABEL: combine_v8i16
-  ; ENABLED: ld.v4.b32
+; ENABLED-LABEL: combine_v8i16(
+; ENABLED:       {
+; ENABLED-NEXT:    .reg .b16 %rs<9>;
+; ENABLED-NEXT:    .reg .b32 %r<20>;
+; ENABLED-NEXT:    .reg .b64 %rd<3>;
+; ENABLED-EMPTY:
+; ENABLED-NEXT:  // %bb.0:
+; ENABLED-NEXT:    ld.param.u64 %rd1, [combine_v8i16_param_0];
+; ENABLED-NEXT:    ld.v4.b32 {%r1, %r2, %r3, %r4}, [%rd1];
+; ENABLED-NEXT:    mov.b32 {%rs1, %rs2}, %r4;
+; ENABLED-NEXT:    mov.b32 {%rs3, %rs4}, %r3;
+; ENABLED-NEXT:    mov.b32 {%rs5, %rs6}, %r2;
+; ENABLED-NEXT:    mov.b32 {%rs7, %rs8}, %r1;
+; ENABLED-NEXT:    ld.param.u64 %rd2, [combine_v8i16_param_1];
+; ENABLED-NEXT:    cvt.u32.u16 %r5, %rs7;
+; ENABLED-NEXT:    cvt.u32.u16 %r6, %rs8;
+; ENABLED-NEXT:    cvt.u32.u16 %r7, %rs5;
+; ENABLED-NEXT:    cvt.u32.u16 %r8, %rs6;
+; ENABLED-NEXT:    cvt.u32.u16 %r9, %rs3;
+; ENABLED-NEXT:    cvt.u32.u16 %r10, %rs4;
+; ENABLED-NEXT:    cvt.u32.u16 %r11, %rs1;
+; ENABLED-NEXT:    cvt.u32.u16 %r12, %rs2;
+; ENABLED-NEXT:    add.s32 %r13, %r5, %r6;
+; ENABLED-NEXT:    add.s32 %r14, %r13, %r7;
+; ENABLED-NEXT:    add.s32 %r15, %r14, %r8;
+; ENABLED-NEXT:    add.s32 %r16, %r15, %r9;
+; ENABLED-NEXT:    add.s32 %r17, %r16, %r10;
+; ENABLED-NEXT:    add.s32 %r18, %r17, %r11;
+; ENABLED-NEXT:    add.s32 %r19, %r18, %r12;
+; ENABLED-NEXT:    st.u32 [%rd2], %r19;
+; ENABLED-NEXT:    ret;
+;
+; DISABLED-LABEL: combine_v8i16(
+; DISABLED:       {
+; DISABLED-NEXT:    .reg .b32 %r<16>;
+; DISABLED-NEXT:    .reg .b64 %rd<3>;
+; DISABLED-EMPTY:
+; DISABLED-NEXT:  // %bb.0:
+; DISABLED-NEXT:    ld.param.u64 %rd1, [combine_v8i16_param_0];
+; DISABLED-NEXT:    ld.u16 %r1, [%rd1];
+; DISABLED-NEXT:    ld.param.u64 %rd2, [combine_v8i16_param_1];
+; DISABLED-NEXT:    ld.u16 %r2, [%rd1+2];
+; DISABLED-NEXT:    ld.u16 %r3, [%rd1+4];
+; DISABLED-NEXT:    ld.u16 %r4, [%rd1+6];
+; DISABLED-NEXT:    ld.u16 %r5, [%rd1+8];
+; DISABLED-NEXT:    ld.u16 %r6, [%rd1+10];
+; DISABLED-NEXT:    ld.u16 %r7, [%rd1+12];
+; DISABLED-NEXT:    ld.u16 %r8, [%rd1+14];
+; DISABLED-NEXT:    add.s32 %r9, %r1, %r2;
+; DISABLED-NEXT:    add.s32 %r10, %r9, %r3;
+; DISABLED-NEXT:    add.s32 %r11, %r10, %r4;
+; DISABLED-NEXT:    add.s32 %r12, %r11, %r5;
+; DISABLED-NEXT:    add.s32 %r13, %r12, %r6;
+; DISABLED-NEXT:    add.s32 %r14, %r13, %r7;
+; DISABLED-NEXT:    add.s32 %r15, %r14, %r8;
+; DISABLED-NEXT:    st.u32 [%rd2], %r15;
+; DISABLED-NEXT:    ret;
   %val0 = load i16, ptr %ptr1, align 16
   %ptr1.1 = getelementptr inbounds i16, ptr %ptr1, i64 1
   %val1 = load i16, ptr %ptr1.1, align 2
@@ -160,8 +568,38 @@ define void @combine_v8i16(ptr noundef align 16 %ptr1, ptr noundef align 16 %ptr
 }
 
 define void @combine_v4i32(ptr noundef align 16 %ptr1, ptr noundef align 16 %ptr2) {
-  ; ENABLED-LABEL: combine_v4i32
-  ; ENABLED: ld.v4.u32
+; ENABLED-LABEL: combine_v4i32(
+; ENABLED:       {
+; ENABLED-NEXT:    .reg .b32 %r<8>;
+; ENABLED-NEXT:    .reg .b64 %rd<3>;
+; ENABLED-EMPTY:
+; ENABLED-NEXT:  // %bb.0:
+; ENABLED-NEXT:    ld.param.u64 %rd1, [combine_v4i32_param_0];
+; ENABLED-NEXT:    ld.v4.u32 {%r1, %r2, %r3, %r4}, [%rd1];
+; ENABLED-NEXT:    ld.param.u64 %rd2, [combine_v4i32_param_1];
+; ENABLED-NEXT:    add.s32 %r5, %r1, %r2;
+; ENABLED-NEXT:    add.s32 %r6, %r5, %r3;
+; ENABLED-NEXT:    add.s32 %r7, %r6, %r4;
+; ENABLED-NEXT:    st.u32 [%rd2], %r7;
+; ENABLED-NEXT:    ret;
+;
+; DISABLED-LABEL: combine_v4i32(
+; DISABLED:       {
+; DISABLED-NEXT:    .reg .b32 %r<8>;
+; DISABLED-NEXT:    .reg .b64 %rd<3>;
+; DISABLED-EMPTY:
+; DISABLED-NEXT:  // %bb.0:
+; DISABLED-NEXT:    ld.param.u64 %rd1, [combine_v4i32_param_0];
+; DISABLED-NEXT:    ld.u32 %r1, [%rd1];
+; DISABLED-NEXT:    ld.param.u64 %rd2, [combine_v4i32_param_1];
+; DISABLED-NEXT:    ld.u32 %r2, [%rd1+4];
+; DISABLED-NEXT:    ld.u32 %r3, [%rd1+8];
+; DISABLED-NEXT:    ld.u32 %r4, [%rd1+12];
+; DISABLED-NEXT:    add.s32 %r5, %r1, %r2;
+; DISABLED-NEXT:    add.s32 %r6, %r5, %r3;
+; DISABLED-NEXT:    add.s32 %r7, %r6, %r4;
+; DISABLED-NEXT:    st.u32 [%rd2], %r7;
+; DISABLED-NEXT:    ret;
   %val0 = load i32, ptr %ptr1, align 16
   %ptr1.1 = getelementptr inbounds i32, ptr %ptr1, i64 1
   %val1 = load i32, ptr %ptr1.1, align 4