diff --git a/src/compiler/parser.ts b/src/compiler/parser.ts
index 247381f02516b..e57a3fa98f390 100644
--- a/src/compiler/parser.ts
+++ b/src/compiler/parser.ts
@@ -3189,7 +3189,8 @@ namespace ts {
             const pos = getNodePos();
             parseExpected(SyntaxKind.TypeOfKeyword);
             const entityName = parseEntityName(/*allowReservedWords*/ true, /*allowPrivateIdentifiers*/ true);
-            const typeArguments = tryParseTypeArguments();
+            // Make sure we perform ASI to prevent parsing the next line's type arguments as part of an instantiation expression.
+            const typeArguments = !scanner.hasPrecedingLineBreak() ? tryParseTypeArguments() : undefined;
             return finishNode(factory.createTypeQueryNode(entityName, typeArguments), pos);
         }
 
diff --git a/tests/baselines/reference/newLineInTypeofInstantiation.js b/tests/baselines/reference/newLineInTypeofInstantiation.js
new file mode 100644
index 0000000000000..b43b677030531
--- /dev/null
+++ b/tests/baselines/reference/newLineInTypeofInstantiation.js
@@ -0,0 +1,9 @@
+//// [newLineInTypeofInstantiation.ts]
+interface Example {
+    (a: number): typeof a
+  
+    <T>(): void
+}
+
+
+//// [newLineInTypeofInstantiation.js]
diff --git a/tests/baselines/reference/newLineInTypeofInstantiation.symbols b/tests/baselines/reference/newLineInTypeofInstantiation.symbols
new file mode 100644
index 0000000000000..2a3ccf8097e86
--- /dev/null
+++ b/tests/baselines/reference/newLineInTypeofInstantiation.symbols
@@ -0,0 +1,12 @@
+=== tests/cases/compiler/newLineInTypeofInstantiation.ts ===
+interface Example {
+>Example : Symbol(Example, Decl(newLineInTypeofInstantiation.ts, 0, 0))
+
+    (a: number): typeof a
+>a : Symbol(a, Decl(newLineInTypeofInstantiation.ts, 1, 5))
+>a : Symbol(a, Decl(newLineInTypeofInstantiation.ts, 1, 5))
+  
+    <T>(): void
+>T : Symbol(T, Decl(newLineInTypeofInstantiation.ts, 3, 5))
+}
+
diff --git a/tests/baselines/reference/newLineInTypeofInstantiation.types b/tests/baselines/reference/newLineInTypeofInstantiation.types
new file mode 100644
index 0000000000000..a57d7df124b95
--- /dev/null
+++ b/tests/baselines/reference/newLineInTypeofInstantiation.types
@@ -0,0 +1,9 @@
+=== tests/cases/compiler/newLineInTypeofInstantiation.ts ===
+interface Example {
+    (a: number): typeof a
+>a : number
+>a : number
+  
+    <T>(): void
+}
+
diff --git a/tests/cases/compiler/newLineInTypeofInstantiation.ts b/tests/cases/compiler/newLineInTypeofInstantiation.ts
new file mode 100644
index 0000000000000..99259acec79f4
--- /dev/null
+++ b/tests/cases/compiler/newLineInTypeofInstantiation.ts
@@ -0,0 +1,5 @@
+interface Example {
+    (a: number): typeof a
+  
+    <T>(): void
+}