diff --git a/src/duckdb.js b/src/duckdb.js
index b0ec8e31..52b7199e 100644
--- a/src/duckdb.js
+++ b/src/duckdb.js
@@ -2,6 +2,7 @@ import {getArrowTableSchema, isArrowTable, loadArrow} from "./arrow.js";
 import {duckdb} from "./dependencies.js";
 import {FileAttachment} from "./fileAttachment.js";
 import {cdn} from "./require.js";
+import {isArqueroTable} from "./table.js";
 
 // Adapted from https://observablehq.com/@cmudig/duckdb-client
 // Copyright 2021 CMU Data Interaction Group
@@ -134,6 +135,8 @@ export class DuckDBClient {
           await insertArrowTable(db, name, source);
         } else if (Array.isArray(source)) { // bare array of objects
           await insertArray(db, name, source);
+        } else if (isArqueroTable(source)) {
+          await insertArqueroTable(db, name, source);
         } else if ("data" in source) { // data + options
           const {data, ...options} = source;
           if (isArrowTable(data)) {
@@ -215,6 +218,14 @@ async function insertArrowTable(database, name, table, options) {
   }
 }
 
+async function insertArqueroTable(database, name, source) {
+  // TODO When we have stdlib versioning and can upgrade Arquero to version 5,
+  // we can then call source.toArrow() directly, with insertArrowTable()
+  const arrow = await loadArrow();
+  const table = arrow.tableFromIPC(source.toArrowBuffer());
+  return await insertArrowTable(database, name, table);
+}
+
 async function insertArray(database, name, array, options) {
   const arrow = await loadArrow();
   const table = arrow.tableFromJSON(array);
diff --git a/src/index.js b/src/index.js
index 29751825..55994f54 100644
--- a/src/index.js
+++ b/src/index.js
@@ -7,5 +7,6 @@ export {
   arrayIsPrimitive,
   isDataArray,
   isDatabaseClient,
+  isArqueroTable,
   __table as applyDataTableOperations
 } from "./table.js";
diff --git a/src/table.js b/src/table.js
index 247fd4fc..fc07f90b 100644
--- a/src/table.js
+++ b/src/table.js
@@ -141,6 +141,11 @@ function isTypedArray(value) {
   );
 }
 
+export function isArqueroTable(value) {
+  // Arquero tables have a `toArrowBuffer` function
+  return value && typeof value.toArrowBuffer === "function";
+}
+
 // __query is used by table cells; __query.sql is used by SQL cells.
 export const __query = Object.assign(
   async (source, operations, invalidation, name) => {
@@ -198,7 +203,7 @@ const loadTableDataSource = sourceCache(async (source, name) => {
     if (/\.(arrow|parquet)$/i.test(source.name)) return loadDuckDBClient(source, name);
     throw new Error(`unsupported file type: ${source.mimeType}`);
   }
-  if (isArrowTable(source)) return loadDuckDBClient(source, name);
+  if (isArrowTable(source) || isArqueroTable(source)) return loadDuckDBClient(source, name);
   return source;
 });
 
@@ -214,7 +219,7 @@ const loadSqlDataSource = sourceCache(async (source, name) => {
     throw new Error(`unsupported file type: ${source.mimeType}`);
   }
   if (isDataArray(source)) return loadDuckDBClient(await asArrowTable(source, name), name);
-  if (isArrowTable(source)) return loadDuckDBClient(source, name);
+  if (isArrowTable(source) || isArqueroTable(source)) return loadDuckDBClient(source, name);
   return source;
 });