diff --git a/doc/source/whatsnew/v0.25.2.rst b/doc/source/whatsnew/v0.25.2.rst
index 69f324211e5b2..627ba0d895dee 100644
--- a/doc/source/whatsnew/v0.25.2.rst
+++ b/doc/source/whatsnew/v0.25.2.rst
@@ -101,7 +101,7 @@ Other
 ^^^^^
 
 - Compatibility with Python 3.8 in :meth:`DataFrame.query` (:issue:`27261`)
--
+- Bug in :meth:`Series.append` where it raised TypeError if tuple of series was passed in 'to_append' param. (:issue:`28410`)
 
 .. _whatsnew_0.252.contributors:
 
diff --git a/pandas/core/series.py b/pandas/core/series.py
index 10d50e89ca92e..8d80416deb525 100644
--- a/pandas/core/series.py
+++ b/pandas/core/series.py
@@ -2729,8 +2729,10 @@ def append(self, to_append, ignore_index=False, verify_integrity=False):
         """
         from pandas.core.reshape.concat import concat
 
-        if isinstance(to_append, (list, tuple)):
+        if isinstance(to_append, list):
             to_concat = [self] + to_append
+        elif isinstance(to_append, tuple):
+            to_concat = [self] + list(to_append)
         else:
             to_concat = [self, to_append]
         return concat(