diff --git a/pandas/_libs/internals.pyi b/pandas/_libs/internals.pyi
index 446ee299698c5..d35d414aaa012 100644
--- a/pandas/_libs/internals.pyi
+++ b/pandas/_libs/internals.pyi
@@ -6,7 +6,10 @@ from typing import (
 
 import numpy as np
 
-from pandas._typing import ArrayLike
+from pandas._typing import (
+    ArrayLike,
+    T,
+)
 
 def slice_len(slc: slice, objlen: int = ...) -> int: ...
 
@@ -50,9 +53,16 @@ class BlockPlacement:
     def append(self, others: list[BlockPlacement]) -> BlockPlacement: ...
 
 
-class Block:
+class SharedBlock:
     _mgr_locs: BlockPlacement
     ndim: int
     values: ArrayLike
 
     def __init__(self, values: ArrayLike, placement: BlockPlacement, ndim: int): ...
+
+class NumpyBlock(SharedBlock):
+    values: np.ndarray
+    def getitem_block_index(self: T, slicer: slice) -> T: ...
+
+class Block(SharedBlock):
+    ...
diff --git a/pandas/_libs/internals.pyx b/pandas/_libs/internals.pyx
index 4295db9d1613c..d7c5882e92f97 100644
--- a/pandas/_libs/internals.pyx
+++ b/pandas/_libs/internals.pyx
@@ -458,14 +458,13 @@ def get_blkno_placements(blknos, group: bool = True):
 
 
 @cython.freelist(64)
-cdef class Block:
+cdef class SharedBlock:
     """
     Defining __init__ in a cython class significantly improves performance.
     """
     cdef:
         public BlockPlacement _mgr_locs
         readonly int ndim
-        public object values
 
     def __cinit__(self, values, placement: BlockPlacement, ndim: int):
         """
@@ -479,7 +478,6 @@ cdef class Block:
         """
         self._mgr_locs = placement
         self.ndim = ndim
-        self.values = values
 
     cpdef __reduce__(self):
         # We have to do some gymnastics b/c "ndim" is keyword-only
@@ -505,3 +503,33 @@ cdef class Block:
 
             ndim = maybe_infer_ndim(self.values, self.mgr_locs)
             self.ndim = ndim
+
+
+cdef class NumpyBlock(SharedBlock):
+    cdef:
+        public ndarray values
+
+    def __cinit__(self, ndarray values, BlockPlacement placement, int ndim):
+        # set values here the (implicit) call to SharedBlock.__cinit__ will
+        #  set placement and ndim
+        self.values = values
+
+    # @final  # not useful in cython, but we _would_ annotate with @final
+    def getitem_block_index(self, slicer: slice) -> NumpyBlock:
+        """
+        Perform __getitem__-like specialized to slicing along index.
+
+        Assumes self.ndim == 2
+        """
+        new_values = self.values[..., slicer]
+        return type(self)(new_values, self._mgr_locs, ndim=self.ndim)
+
+
+cdef class Block(SharedBlock):
+    cdef:
+        public object values
+
+    def __cinit__(self, object values, BlockPlacement placement, int ndim):
+        # set values here the (implicit) call to SharedBlock.__cinit__ will
+        #  set placement and ndim
+        self.values = values
diff --git a/pandas/core/internals/blocks.py b/pandas/core/internals/blocks.py
index b18c25b8092a2..b267c40bd9f63 100644
--- a/pandas/core/internals/blocks.py
+++ b/pandas/core/internals/blocks.py
@@ -5,7 +5,7 @@
 from typing import (
     TYPE_CHECKING,
     Any,
-    Union,
+    Callable,
     cast,
 )
 import warnings
@@ -138,7 +138,7 @@ def newfunc(self, *args, **kwargs) -> list[Block]:
     return cast(F, newfunc)
 
 
-class Block(libinternals.Block, PandasObject):
+class Block(PandasObject):
     """
     Canonical n-dimensional unit of homogeneous dtype contained in a pandas
     data structure
@@ -147,6 +147,8 @@ class Block(libinternals.Block, PandasObject):
     """
 
     values: np.ndarray | ExtensionArray
+    ndim: int
+    __init__: Callable
 
     __slots__ = ()
     is_numeric = False
@@ -313,7 +315,6 @@ def getitem_block(self, slicer) -> Block:
 
         return type(self)(new_values, new_mgr_locs, self.ndim)
 
-    @final
     def getitem_block_index(self, slicer: slice) -> Block:
         """
         Perform __getitem__-like specialized to slicing along index.
@@ -1371,7 +1372,7 @@ def interpolate(
         return self.make_block_same_class(new_values)
 
 
-class ExtensionBlock(EABackedBlock):
+class ExtensionBlock(libinternals.Block, EABackedBlock):
     """
     Block for holding extension types.
 
@@ -1660,7 +1661,13 @@ def _unstack(self, unstacker, fill_value, new_placement):
         return blocks, mask
 
 
-class NumericBlock(Block):
+class NumpyBlock(libinternals.NumpyBlock, Block):
+    values: np.ndarray
+
+    getitem_block_index = libinternals.NumpyBlock.getitem_block_index
+
+
+class NumericBlock(NumpyBlock):
     __slots__ = ()
     is_numeric = True
 
@@ -1771,16 +1778,15 @@ def fillna(
         return [self.make_block_same_class(values=new_values)]
 
 
-class DatetimeLikeBlock(NDArrayBackedExtensionBlock):
-    """Mixin class for DatetimeLikeBlock, DatetimeTZBlock."""
+class DatetimeLikeBlock(libinternals.Block, NDArrayBackedExtensionBlock):
+    """Block for datetime64[ns], timedelta64[ns]."""
 
     __slots__ = ()
     is_numeric = False
-
     values: DatetimeArray | TimedeltaArray
 
 
-class DatetimeTZBlock(ExtensionBlock, DatetimeLikeBlock):
+class DatetimeTZBlock(ExtensionBlock, NDArrayBackedExtensionBlock):
     """ implement a datetime64 block with a tz attribute """
 
     values: DatetimeArray
@@ -1794,18 +1800,15 @@ class DatetimeTZBlock(ExtensionBlock, DatetimeLikeBlock):
     putmask = NDArrayBackedExtensionBlock.putmask
     fillna = NDArrayBackedExtensionBlock.fillna
 
-    # error: Incompatible types in assignment (expression has type
-    # "Callable[[NDArrayBackedExtensionBlock], bool]", base class "ExtensionBlock"
-    # defined the type as "bool")  [assignment]
-    is_view = NDArrayBackedExtensionBlock.is_view  # type: ignore[assignment]
+    get_values = NDArrayBackedExtensionBlock.get_values
+
+    is_view = NDArrayBackedExtensionBlock.is_view
 
 
-class ObjectBlock(Block):
+class ObjectBlock(NumpyBlock):
     __slots__ = ()
     is_object = True
 
-    values: np.ndarray
-
     @maybe_split
     def reduce(self, func, ignore_failures: bool = False) -> list[Block]:
         """
@@ -2030,7 +2033,7 @@ def ensure_block_shape(values: ArrayLike, ndim: int = 1) -> ArrayLike:
             # TODO(EA2D): https://github.com/pandas-dev/pandas/issues/23023
             # block.shape is incorrect for "2D" ExtensionArrays
             # We can't, and don't need to, reshape.
-            values = cast(Union[np.ndarray, DatetimeArray, TimedeltaArray], values)
+            values = cast("np.ndarray | DatetimeArray | TimedeltaArray", values)
             values = values.reshape(1, -1)
 
     return values