diff --git a/Python/ceval.c b/Python/ceval.c
index 47d068edac2743..8b6f8bf2e15f3a 100644
--- a/Python/ceval.c
+++ b/Python/ceval.c
@@ -948,11 +948,15 @@ _PyObjectArray_Free(PyObject **array, PyObject **scratch)
 #include "generated_cases.c.h"
 #endif
 
-#if (defined(__GNUC__) && !defined(__clang__)) && defined(__x86_64__)
+#if (defined(__GNUC__) && __GNUC__ >= 10 && !defined(__clang__)) && defined(__x86_64__)
 /*
- * gh-129987: The SLP autovectorizer can cause poor code generation for opcode
- * dispatch, negating any benefit we get from vectorization elsewhere in the
- * interpreter loop.
+ * gh-129987: The SLP autovectorizer can cause poor code generation for
+ * opcode dispatch in some GCC versions (observed in GCCs 12 through 15,
+ * probably caused by https://gcc.gnu.org/bugzilla/show_bug.cgi?id=115777),
+ * negating any benefit we get from vectorization elsewhere in the
+ * interpreter loop. Disabling it significantly affected older GCC versions
+ * (prior to GCC 9, 40% performance drop), so we have to selectively disable
+ * it.
  */
 #define DONT_SLP_VECTORIZE __attribute__((optimize ("no-tree-slp-vectorize")))
 #else