diff --git a/Lib/cProfile.py b/Lib/cProfile.py
index 47aacf9e2d494e..406a9b7cf11be9 100755
--- a/Lib/cProfile.py
+++ b/Lib/cProfile.py
@@ -191,7 +191,12 @@ def main():
                 '__package__': None,
                 '__cached__': None,
             }
-        runctx(code, globs, None, options.outfile, options.sort)
+        try:
+            runctx(code, globs, None, options.outfile, options.sort)
+        except BrokenPipeError as exc:
+            # Prevent "Exception ignored" during interpreter shutdown.
+            sys.stdout = None
+            sys.exit(exc.errno)
     else:
         parser.print_usage()
     return parser
diff --git a/Lib/profile.py b/Lib/profile.py
index 9df4435c5ae837..df4450dac6a1b6 100755
--- a/Lib/profile.py
+++ b/Lib/profile.py
@@ -611,7 +611,12 @@ def main():
                 '__package__': None,
                 '__cached__': None,
             }
-        runctx(code, globs, None, options.outfile, options.sort)
+        try:
+            runctx(code, globs, None, options.outfile, options.sort)
+        except BrokenPipeError as exc:
+            # Prevent "Exception ignored" during interpreter shutdown.
+            sys.stdout = None
+            sys.exit(exc.errno)
     else:
         parser.print_usage()
     return parser
diff --git a/Misc/NEWS.d/next/Library/2020-10-11-13-48-03.bpo-42005.Jq6Az-.rst b/Misc/NEWS.d/next/Library/2020-10-11-13-48-03.bpo-42005.Jq6Az-.rst
new file mode 100644
index 00000000000000..be4ed7f55ffded
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2020-10-11-13-48-03.bpo-42005.Jq6Az-.rst
@@ -0,0 +1,2 @@
+Fix CLI of :mod:`cProfile` and :mod:`profile` to catch
+:exc:`BrokenPipeError`.