diff --git a/Include/Python.h b/Include/Python.h
index 6ee52e74928373..7f7ed5981c5c77 100644
--- a/Include/Python.h
+++ b/Include/Python.h
@@ -116,6 +116,7 @@
 #include "sliceobject.h"
 #include "cellobject.h"
 #include "iterobject.h"
+#include "cpython/initconfig.h"
 #include "genobject.h"
 #include "descrobject.h"
 #include "genericaliasobject.h"
@@ -127,8 +128,6 @@
 
 #include "codecs.h"
 #include "pyerrors.h"
-
-#include "cpython/initconfig.h"
 #include "pythread.h"
 #include "pystate.h"
 #include "context.h"
diff --git a/Include/cpython/pystate.h b/Include/cpython/pystate.h
index f292da1d3c6c5e..0eb601fd7c55ec 100644
--- a/Include/cpython/pystate.h
+++ b/Include/cpython/pystate.h
@@ -6,8 +6,6 @@
 extern "C" {
 #endif
 
-#include "cpython/initconfig.h"
-
 PyAPI_FUNC(int) _PyInterpreterState_RequiresIDRef(PyInterpreterState *);
 PyAPI_FUNC(void) _PyInterpreterState_RequireIDRef(PyInterpreterState *, int);
 
diff --git a/Misc/NEWS.d/next/C API/2021-11-09-15-42-11.bpo-39026.sUnYWn.rst b/Misc/NEWS.d/next/C API/2021-11-09-15-42-11.bpo-39026.sUnYWn.rst
new file mode 100644
index 00000000000000..77a01197921529
--- /dev/null
+++ b/Misc/NEWS.d/next/C API/2021-11-09-15-42-11.bpo-39026.sUnYWn.rst	
@@ -0,0 +1,2 @@
+Fix Python.h to build C extensions with Xcode: remove a relative include
+from ``Include/cpython/pystate.h``.