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The corr method for DataFrames is exceedingly useful, especially since one can specify methods other than the Pearson correlation. I think it would be nice if this same argument were available when using corrwith. Perhaps there is another workaround, but right now if one wants to calculate all the Spearman (say) correlations with a specific variable, it seems necessary to calculate the full Spearman correlation matrix and subset to the column you care about.